Find Hotels in South Main, Houston

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South Main – discover 6 hotels

Holiday Inn Express & Suites Houston S - Medical Ctr Area

Hotel in Braeswood Place, Houston

Excellent

1 review

Holiday Inn Express & Suites Houston Medical Center, an IHG Hotel, offers comfort and convenience in Braeswood Place. Enjoy free WiFi, self-parking, an outdoor pool, and a fitness center. The hotel features a business center, laundry services, and accessible amenities. Nearby attractions include NRG Stadium and MD Anderson Cancer Center.

From $148 per night

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Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel

Hotel in Astrodome, Houston

Very Good

0 reviews

Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel, offers a comfortable stay with amenities like free WiFi, a pool, and a fitness center. Located in the Astrodome neighborhood, it's close to NRG Stadium and medical facilities. Enjoy dining at Trellis restaurant and relax at the bar/lounge.

From $140 per night

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Comfort Suites near Texas Medical Center - NRG Stadium

Hotel in South Main, Houston

Very Good

0 reviews

Comfort Suites near Texas Medical Center - NRG Stadium in Houston, TX, offers a convenient stay with amenities like an outdoor pool, fitness center, and business facilities. Located in South Main, it's close to NRG Stadium and other attractions. Enjoy free breakfast, WiFi, and spacious suites with modern conveniences.

From $130 per night

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Quality Inn & Suites NRG Park - Medical Center

Hotel in South Main, Houston

Average

1 review

Quality Inn & Suites NRG Park - Medical Center in Houston offers free WiFi, self-parking, and a snack bar. Guests can enjoy a fitness center, 24/7 front desk, and business facilities. Located in South Main, it's close to NRG Stadium and The Woman's Hospital of Texas. Pets are welcome for a surcharge.

From $79 per night

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Astro Best Inn

Hotel in Braeswood Place, Houston

No reviews

0 reviews

Astro Best Inn in Houston's Braeswood Place offers 2-star accommodations with free WiFi, free self-parking, and a 24/7 front desk. Conveniently located near NRG Stadium and Rice Stadium, the motel features air-conditioned rooms, concierge services, and laundry facilities. Nearby attractions include Kelsey Seybold, just 1.57 miles away.

From $91 per night

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Motel 6 Houston, TX - Medical Center/NRG Stadium

Hotel in Willow Meadows/Willowbend Area, Houston

Average

0 reviews

Studio 6 Houston, TX – Medical Center NRG Stadium is a 2-star motel in the Willow Meadows/Willowbend Area. It offers free WiFi, free parking, a bar/lounge, and a snack bar. Guests can enjoy an outdoor pool, 24/7 front desk, and laundry facilities. Pets are welcome for a surcharge.

From $64 per night

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Candlewood Suites Houston Medical Center, an IHG Hotel

Hotel in South Main, Houston

Very Good

0 reviews

Candlewood Suites Houston Medical Center, an IHG Hotel, offers free WiFi, self parking, and a 24-hour fitness center. Located in South Main, it's close to NRG Stadium and NRG Park. Enjoy amenities like a business center, concierge services, and pet-friendly rooms. Ideal for both short and extended stays.

From $90 per night

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Staybridge Suites Houston - Medical Center, an IHG Hotel

Hotel in Braeswood Place, Houston

Very Good

0 reviews

Staybridge Suites Houston - Medical Center, an IHG Hotel, offers a comfortable stay with amenities like free WiFi, self-parking, and an electric car charging station. Enjoy the outdoor pool, fitness center, and complimentary breakfast. Located in Braeswood Place, it's close to NRG Park and MD Anderson Cancer Center. Pets are welcome.

From $159 per night

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Budget hotels in South Main

Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel

Hotel in Astrodome, Houston

Very Good

•

14 reviews

From $140 per night

Comfort Suites near Texas Medical Center - NRG Stadium

Hotel in South Main, Houston

Very Good

•

8 reviews

From $130 per night

Quality Inn & Suites NRG Park - Medical Center

Hotel in South Main, Houston

Average

•

7 reviews

From $79 per night

Astro Best Inn

Hotel in Braeswood Place, Houston

From $91 per night

Candlewood Suites Houston Medical Center, an IHG Hotel

Hotel in South Main, Houston

Very Good

•

10 reviews

From $90 per night

Popular hotels in South Main with free breakfast

Holiday Inn Express & Suites Houston S - Medical Ctr Area

Hotel in Braeswood Place, Houston

Excellent

•

8 reviews

From $148 per night

Quality Inn & Suites NRG Park - Medical Center

Hotel in South Main, Houston

Average

•

7 reviews

From $79 per night

Staybridge Suites Houston - Medical Center, an IHG Hotel

Hotel in Braeswood Place, Houston

Very Good

•

11 reviews

From $159 per night

Where to stay in South Main

Days Inn & Suites by Wyndham Downtown/University of Houston

Southeast Houston

Southeast Houston boasts 39 hotels, with prices ranging from $34 to $249, averaging around $104. Popular choices include La Quinta Inn & Suites by Wyndham Houston Hobby Airport, Super 8 by Wyndham Houston Hobby Airport South, and Quality Suites Houston Hobby Airport. Visitors can explore the Houston Natural Science Museum, Hermann Park, and the Houston Zoo. The area is also home to Texas Southern University and the University of Houston. For those interested in unique attractions, the Orange Show Center and the 1940 Air Terminal Museum are must-sees.

39 stays

From $34 per night

Downtown Houston

Downtown Houston boasts 32 hotels, with prices ranging from $148 to $617, averaging around $234. Among the most popular stays are the Athens Hotel Suites, The Rusk House, and Best Western Plus Downtown Inn & Suites. Visitors can explore the George R. Brown Convention Center, take a stroll through Discovery Green, or catch a game at Minute Maid Park. Other notable hotels include Club Quarters Hotel Downtown, Houston, and The Whitehall Houston. The area is also home to the Houston Theater District and the Downtown Aquarium, making it a lively destination for both business and leisure travelers.

32 stays

From $148 per night

Red Roof Inn PLUS+ & Suites Houston - IAH Airport SW

Northside

Northside boasts 31 hotels, with prices ranging from $49 to $206, averaging around $98. Popular choices include the Days Inn & Suites by Wyndham Houston North/Aldine, Heights House Hotel, and the Ascend Hotel Collection. If you're looking for some fun, check out the Zuma Fun Center North Houston or catch a show at The Catastrophic Theatre. Art enthusiasts might enjoy the Artcar Museum. For a bit of local flavor, a visit to Saint Arnold Brewery is a must. Whether you're skating at North Houston Skate Park or exploring the National Museum of Funeral History, there's plenty to see and do.

31 stays

From $49 per night

Days Inn by Wyndham Humble/Houston Intercontinental Airport

FM 1960

FM 1960 boasts 29 hotels, with prices ranging from $62 to $138, averaging around $83. Some of the most popular places to stay include the Americas Best Value Inn Aldine Westfield, Comfort Suites Northwest - Cy - Fair, La Quinta by Wyndham Houston Willowbrook Vintage Park, Travelodge by Wyndham Houston Cy-Fair, and Econo Lodge Inn & Suites Humble FM1960 - IAH Airport. While there, you might want to check out Stone Moves Indoor Rock Climbing or visit the Cypress Fairbanks Medical Center. For those interested in healthcare facilities, Providence Hospital of North Houston is also nearby.

29 stays

From $62 per night

La Quinta Inn & Suites by Wyndham Houston Channelview

Northeast Houston

Northeast Houston boasts 26 hotels, with prices ranging from $56 to $171 and an average of $92. Popular options include the Palace Inn Blue Houston East Beltway 8, Motel 6 Houston, TX - East, and La Quinta Inn & Suites by Wyndham Houston East at Normandy. For some fun, check out the Lockwood Skating Palace or tee off at the River Terrace Golf Course. Nature lovers can explore Sheldon Lake State Park. Whether you're visiting for business or leisure, there's a variety of accommodations and attractions to make your stay enjoyable.

26 stays

From $56 per night

Houston Central Business District

Houston Central Business District is home to 26 hotels, with prices ranging from $104 to $617, averaging around $234. Among the most popular places to stay are Athens Hotel Suites, The Rusk House, Best Western Plus Downtown Inn & Suites, Club Quarters Hotel Downtown, Houston, and The Whitehall Houston. While exploring, you can check out the George R. Brown Convention Center, take a stroll through Discovery Green, or catch a game at the Toyota Center. The area also boasts the Houston Theater District and the bustling Shops at Houston Center, making it a vibrant destination for visitors.

26 stays

From $104 per night

Best Western Plus Houston Energy Corridor

Memorial

Memorial boasts 24 hotels, with prices ranging from $42 to $590, averaging around $152. Popular choices include Motel 6 Houston, TX - I-10 West, Comfort Inn & Suites Houston I-10 West Energy Corridor, Drury Inn & Suites Houston Near the Galleria, Staybridge Suites Houston West / Energy Corridor, an IHG Hotel, and Hotel ZaZa Houston Memorial City. While there, you can explore the Houstonian Golf Club, take a stroll through the Edith L. Moore Nature Sanctuary, or shop at Memorial City Mall. The area also features CityCentre and the Houston Arboretum and Nature Center, making it a great spot for both relaxation and adventure.

24 stays

From $42 per night

The Galleria

The Galleria boasts 21 hotels, with prices ranging from $86 to $671, and an average of $209. Among the most popular places to stay are the Extended Stay America Suites Houston Galleria Uptown, Drury Inn & Suites Houston Near the Galleria, and La Quinta Inn & Suites by Wyndham Houston Galleria Area. While there, you can explore the Ice at the Galleria, take a stroll through the River Oaks District, or marvel at the Williams Tower. Other notable hotels include Extended Stay America Suites Houston Galleria Westheimer and Hotel Vesper, Houston, a Tribute Portfolio Hotel.

21 stays

From $86 per night

Staybridge Suites Houston Galleria Area, an IHG Hotel

Uptown

Uptown boasts 21 hotels, with prices ranging from $86 to $671 and an average of $217. Popular choices include the Extended Stay America Suites Houston Galleria Uptown, Drury Inn & Suites Houston Near the Galleria, and La Quinta Inn & Suites by Wyndham Houston Galleria Area. While there, you can check out Ice at the Galleria, Williams Tower, and Uptown Park. Other notable hotels are the Extended Stay America Suites Houston Galleria Westheimer and Hotel Vesper, Houston, a Tribute Portfolio Hotel. Whether you're visiting for business or leisure, Uptown has plenty to offer.

21 stays

From $86 per night

Westchase

Westchase boasts 21 hotels, offering a range of accommodations to suit various budgets. Prices for a stay can vary from $68 to $177, with an average of $102. Among the most popular hotels are the Holiday Inn - Houston Westchase, an IHG Hotel, and the Holiday Inn Express and Suites Houston Westchase - Westheimer, an IHG Hotel. Other notable options include Sleep Inn & Suites near Westchase, Sonesta Essential Houston Westchase, and Champions Club Westchase, Houston. While there, you might find yourself near the headquarters of Philips 66 or Halliburton, or perhaps exploring Remington College.

21 stays

From $68 per night

About South Main

South Main boasts 6 hotels, offering a range of accommodations to suit various budgets. Prices for a stay in this area can vary from $45 to $130, with an average cost of around $91. Among the most popular places to stay are the Scottish Inn And Suites Nrg Park/Texas Medical Center - Houston, Quality Inn & Suites NRG Park - Medical Center, and Motel 6 Houston, TX - Medical Center/NRG Stadium. Other notable options include Staybridge Suites Houston - Medical Center, an IHG Hotel, and Comfort Suites near Texas Medical Center - NRG Stadium.